Design, synthesis and biological evaluation of 3-(2-aminooxazol-5-yl)-2H-chromen-2-one derivatives
نویسندگان
چکیده
منابع مشابه
(E)-6-Bromo-3-{2-[2-(4-chlorobenzylidene)hydrazinyl]thiazol-5-yl}-2H-chromen-2-one
In the title compound, C(19)H(11)N(3)O(2)SClBr, the chromene ring system and the thia-zole ring are each approximately planar, with maximum deviations of 0.033 (3) Å and 0.006 (3) Å, respectively. The mol-ecule adopts an E configuration about the central C=N double bond. The central thia-zole ring makes dihedral angles of 9.06 (14)° and 12.07 (11)° with the chloro-substituted phenyl ring and th...
متن کامل3-(9H-Carbazol-9-yl)-2H-chromen-2-one
The title compound, C(21)H(13)NO(2), was prepared as an example of a new synthesis of carbazoles from a cyclic dibenzo-iodo-lium salt via a twofold Pd-catalysed aryl-ation of a primary amine. The two essentially planar π-subsystems [maximum deviations from the mean square plane of 0.038 (2) Å in the carbazole and 0.059 (2) Å in the coumarine unit] open a dihedral angle of 63.05 (4)°. Two mol-ec...
متن کامل4-Hydroxy-3-[(4-hydroxy-6,7-dimethyl-2-oxo-2H-chromen-3-yl)(4-oxo-4H-chromen-3-yl)methyl]-6,7-dimethyl-2H-chromen-2-one
In the title compound, C(32)H(24)O(8), the mol-ecular structure is disordered over two positions with refined site occupancies of 0.8746 (10) and 0.1254 (10). The mean plane of the three chromeno rings make dihedral angles with each other of 65.12 (4), 62.91 (4) and 59.70 (4)° in the major occupancy component and 59.1 (3), 66.1 (3) and 58.8 (3)° in the minor component. Intra-molecular O-H⋯O hyd...
متن کاملSynthesis and Biological Evaluation of 2-isonicotinyl 3, 5-diaryl -2h-(3-tetrazolium) Chloride Derivatives
A synthesis of 2-Isonicotinyl 3, 5-diaryl -2H-(3-tetrazolium) chloride (5) was performed starting from isonicotinic hydrazide (1). The treatment of 1 with various substituted aromatic aldehydes afforded the corresponding Schiff’s bases 3. The Schiff’s bases are converted into a series of aryl formazan via diazocoupling which underwent cyclization in the presence of H2O2 and KMnO4 to give substi...
متن کاملSynthesis and in-vitro antimicrobial screening of 3-cinnamoyl coumarin and 3-[3-(1H-indol-2-yl)-3-aryl-propanoyl]-2H-chromen-2-ones
An efficient synthesis of some novel coumarin derivatives via 1, 4- Michael addition of indole to coumarin chalcones catalyzed by cellulose sulphonic acid (CSA) under solvent free conditions is described. The corresponding Michael addition products were obtained in good to excellent yield. The synthesized compounds were screened for their antibacterial activity against E. coli, S. aureus and an...
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ژورنال
عنوان ژورنال: Chemistry Central Journal
سال: 2018
ISSN: 1752-153X
DOI: 10.1186/s13065-018-0499-x